Causal Relationship Between Genetically Determined Free Fatty Acids and Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study.

ABSTRACT:

Objective

This study aimed to evaluate whether the ten-individual plasma-level of free fatty acids (FFAs) affect the risk of nonalcoholic fatty liver disease (NAFLD) which is featured by triglycerides (TGs) deposition because the observational studies are limited and conflicting about the causal effect between FFAs and NAFLD.

Design and methods

This analysis was a large genome-wide association study (GWAS) summary statistic. Fourteen independent single-nucleotide polymorphisms (SNPs) without linkage disequilibrium (r ² < 0.005) that were strongly associated (p < 5 × 10^-8) with FFAs were chosen as instrumental variables to estimate the causal effect of genetic variants on the levels of 10 phospholipid FAs through GWAS, and summary estimates

SUBMITTER: Li K 

PROVIDER: S-EPMC12520819 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature