Efficacy, immunogenicity, and safety of pneumococcal conjugate vaccine in children: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Pneumococcal infections are the leading cause of childhood morbidity and mortality, and efforts have been made to search for effective means of prevention and control to reduce their serious threat to children's health. This study intends to investigate the efficacy, immunogenicity, and safety of pneumococcal conjugate vaccine (PCV) in children.

Methods

A search was conducted in PubMed, Web of Science, Cochrane Library, and Embase up to June 19, 2024. Children aged 0-2 years were included, and PCV was given in the intervention group and a placebo in the control group. The outcomes were immunogenicity, safety, and adverse events. Meta-analyses were conducted using RevMan and Stata17, and the Cochrane Risk of Bias 2.0 was utilized for quality assessment.

Results

SUBMITTER: Dai Q 

PROVIDER: S-EPMC12520882 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature