Association of overt hypothyroidism with risks of cognitive impairment: a meta-analysis and systematic review.

ABSTRACT:

Background

Studies examining the relationship between overt hypothyroidism (oHT) and the risk of cognitive impairment (CI) have yielded mixed results. This study aimed to evaluate the association between oHT and the risk of CI.

Methods

We systematically searched relevant studies published up to March 2025. Data were extracted independently by two investigators. Overall odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated using a random-effects model. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of cohort and case-control studies, while the Agency for Healthcare Research and Quality (AHRQ) scale was used for cross-sectional studies. Results were reported following PRISMA guidelines.

Results

A total of 11 studies involving 1,190,

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12520926 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature