Vascular recanalization exacerbates BBB permeability after ischemic stroke.

ABSTRACT:

Introduction

Ischemic stroke is a common and serious neurological disease. After cerebral ischemia occurs, the integrity of the BBB is disrupted, leading to increased permeability, causing pathophysiological changes such as brain edema and hemorrhagic transformation, which aggravates neuronal damage. Such changes become more obvious after the recovery of blood flow. However, the effect of vascular recanalization on blood-brain barrier leakage is poorly known.

Methods

Mice were divided into the recanalization group and the non-recanalization group. Mice in the recanalization group suffered from the middle cerebral artery occlusion and were reperfused 60 min later. Mice in the non-recanalization group suffered from permanent occlusion of the middle cerebral artery. The permeab

SUBMITTER: Wang RF 

PROVIDER: S-EPMC12520948 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature