Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells.

ABSTRACT:

Background

Chlorogenic acid (CGA) is a polyphenolic compound widely present in plants. It is primarily extracted from the leaves of Eucommia ulmoides, a native medicinal herb.

Purpose

This study aimed to investigate the cardioprotective effects of CGA on myocardial infarction (MI) by modulating mitochondrial damage and mitophagy through the PINK1/Parkin signaling pathway.

Methods

In vitro, H9C2 cardiomyocytes were treated with varying concentrations of CGA to assess cell viability, oxidative stress, mitochondrial function, and mitophagy markers (PINK1/Parkin) and mitophagic flux. In vivo, There are a total of 18 SD rats, which are randomly divided into Sham, MI, and CGA groups. MI was induced in SD rats via coronary artery ligation, followed by tail vein

SUBMITTER: Ling H 

PROVIDER: S-EPMC12520970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature