Neoadjuvant systemic therapy for hepatocellular carcinoma: challenges and opportunities-a narrative review.

ABSTRACT:

Background and objective

Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality rate worldwide. Surgical resection, liver transplantation (LT), and thermal ablation are primary curative methods for early-stage HCC. However, the high recurrence rate following surgical intervention is the primary factor contributing to the unfavorable prognosis. Therefore, the critical aspect in improving the overall survival of HCC lies in reducing the postoperative recurrence rate. This review is aimed at summarizing the current evidence base regarding the safety and efficacy of systemic therapy administered in the neoadjuvant context for patients with resectable HCC. Furthermore, we will offer a perspective on the potential future trajectories of systemic therapy as a

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12521018 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature