Development of scoring models to predict early pancreatic cancer risk in new-onset diabetes mellitus patients.

ABSTRACT:

Background

Diabetes mellitus is a risk factor of pancreatic cancer (PC). We aimed to develop risk models to predict PC within 1- and 3-year in new onset diabetes mellitus (NODM).

Methods

We utilized territory-wide electronic healthcare database to identify NODM patients [fasting glucose ≥7 mmol/L and/or hemoglobin A1c (HbA1c) ≥6.5%] between 2008 and 2017, and observed for three years until PC development, pancreatectomy or death. Outcome of interest was PC at 1- and 3-year. Clinical variables included age, sex, acute pancreatitis history, body mass index (BMI), blood glucose, lipid profile, estimated glomerular filtration rate (eGFR), alanine transaminase (ALT), alkaline phosphatase (ALP), hemoglobin and baseline medication use {metformin, insulin and other anti-diabetic dru

SUBMITTER: Cheung KS 

PROVIDER: S-EPMC12521035 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature