Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.

ABSTRACT:

Background

The relationship between regional adiposity and dementia remains poorly understood.

Methods

This study included 440 861 UK Biobank participants initially free of dementia, stroke and cancer. Hazard ratios (HRs) and 95% confidence intervals (CIs) of dementia across quartiles of waist circumference (WC) or hip circumference (HC) were calculated, after multivariable adjustment with mutual adjustment for WC and HC. The potential mediating roles of 21 biomarkers covering distinct metabolic pathways were assessed. In a subsample with body composition quantified by dual-energy X-ray absorptiometry, the associations of android and gynoid fatness with magnetic resonance imaging-derived volumetric brain measures were further assessed.

Results

Over a median follow-up

SUBMITTER: Liu ZY 

PROVIDER: S-EPMC12521049 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature