Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations.

ABSTRACT: Ethnic variabilities can affect the outcome of drug pharmacokinetics (PK) and drug-drug interactions (DDI). This work aimed to develop four North American (NA) sub-populations: White, African American, Asian American, and Hispanic_Latino suitable for physiologically based pharmacokinetic (PBPK) modeling and simulations. Demographic data and tissue weight/volume, blood flows, cardiac output, plasma protein levels, hematocrit, enzyme and transporter abundances/frequencies, serum creatinine, glomerular filtration rate, and gastrointestinal transit times for the different populations were collated. Equations describing various covariate relationships for these physiological parameters were developed for each ethnicity. Some key population differences that can affect drug PK were higher CYP3A5

SUBMITTER: Ezuruike U 

PROVIDER: S-EPMC12521061 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature