CD44 and Snail1 Expression Predicts Poor Prognosis of Oral Squamous Cell Carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) remains a challenging malignancy with poor 5-year survival rates due to diagnosis at an advanced stage and a high likelihood of recurrence and metastasis. These aggressive traits may be influenced by cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT).

Methods

This study investigated the prognostic significance of the CSC marker CD44 and EMT-related proteins (Snail1, Snail2, E-cadherin, N-cadherin) in 132 OSCCs using immunohistochemistry. The comprehensive survival analysis included univariate and multivariate (stepwise method) Cox regression for disease-specific survival (DSS) and disease-free survival (DFS), Kaplan-Meier curves based on log-rank testing, and receiver operating characteristic (ROC) analysis to a

SUBMITTER: Marques CE 

PROVIDER: S-EPMC12521071 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature