<i>Akkermansia muciniphila</i> alleviates cognitive impairment and neuroinflammation induced by blunt chest trauma.

ABSTRACT:

Background

Blunt chest trauma, commonly caused by traffic accidents, falls, and violent incidents, results in both direct mechanical injury to the thoracic cavity-leading to increased intrathoracic pressure and vascular rupture-and indirect effects on the central nervous system (CNS), causing extensive damage that severely impacts patient health and quality of life. Akkermansia muciniphila (AKK), a probiotic bacterium inhabiting the gut mucus layer, modulates gut microbiota and metabolites, with potential therapeutic effects on various neurological disorders through the gut-brain axis.

Methods

Mice were divided into four groups: control, trauma, trauma+PBS, and trauma+AKK. AKK bacterial suspension was administered via gavage for three weeks. Behavioral tests including

SUBMITTER: Liu L 

PROVIDER: S-EPMC12521121 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature