Effect of Precision-based HD-tDCS Over Conventional HD-tDCS in Young-onset Mania: Protocol for an Active Comparison fMRI and TMS Study.

ABSTRACT:

Background

As more accurate neuromodulation systems combining high-resolution electroencephalogram (EEG) and anatomical biomarkers develop, it is prudent to evaluate how refined and effective precision neuromodulation is compared to conventional techniques. Considering the growing incidence and the lack of studies outlining an optimal treatment approach, which often leads to a poorer prognosis, young-onset mania presents an ideal challenge for such a comparison.

Novelty

This study aims to be the first to directly compare precision and conventional neuromodulation in child and adolescent populations. It also seeks to study and compare, for the first time, changes in neuroimaging parameters caused by precision and conventional techniques. By correlating perturbation-induced ch

SUBMITTER: Das S 

PROVIDER: S-EPMC12521149 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature