Migraine is associated with a higher risk of ischemic and hemorrhagic stroke: an analysis of the <i>All of Us</i> database.

ABSTRACT:

Background

While prior studies suggest an increased risk of stroke among individuals with migraine, particularly those with migraine with aura, data on how specific migraine characteristics and comorbidities influence this risk across diverse populations remain limited. The All of Us database provides a unique opportunity to address this gap given its large sample size and inclusion of historically underrepresented groups.

Methods

A cross-sectional case-control analysis using multivariable regression models accounting for vascular risk factors and comorbidities was performed to compare the risk of stroke between individuals with and without migraine, odds ratios (OR) using a 95% confidence interval (CI) were calculated.

Results

Within the All of Us datab

SUBMITTER: Seah N 

PROVIDER: S-EPMC12521163 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature