Establishing a nomogram for post-hepatectomy liver failure prediction in hepatocellular carcinoma based on pre-operative and perioperative parameters.

ABSTRACT:

Objective

Post-hepatectomy liver failure (PHLF) is a severe complication for hepatocellular carcinoma (HCC) patients post-surgery. This study explores PHLF risk factors and creates a nomogram for prediction using pre- and intraoperative factors.

Methods

We retrospectively analyzed 654 patients who underwent hepatectomy. Eligible patients were randomly divided into training and internal validation cohorts in a 7:3 ratio. Key variables for nomogram construction were determined through integrated Least Absolute Shrinkage and Selection Operator (LASSO) and multivariate logistic regression analyses. The nomogram's performance was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis.

Results

Among 228 eligible patie

SUBMITTER: Wang D 

PROVIDER: S-EPMC12521178 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature