A prognostic framework integrating endoplasmic reticulum stress dynamics reveals clinical stratification and differential prognostic attributes in osteosarcoma patients.

ABSTRACT:

Background

Endoplasmic reticulum (ER) stress is recognized as a pivotal factor in the initiation and advancement of osteosarcoma; however, its implications for patient prognosis remain poorly understood.

Methods

Our objective was to elucidate the prognostic implications and immune infiltration patterns associated with endoplasmic reticulum (ER) stress in osteosarcoma patients through the synthesis of existing osteosarcoma datasets and the application of advanced bioinformatics methodologies.

Results

Our findings elucidate distinct and heterogeneous expression patterns of endoplasmic reticulum (ER) stress-related genes in osteosarcoma, contrasting sharply with those identified in osteocytes and mesenchymal stem cells. We developed a robust ER stress model comprising te

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12521199 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature