Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system.

ABSTRACT:

Background

Dermatomyositis (DM) is an autoimmune disease that may be triggered by certain medications. However, most studies have focused on specific drugs, lacking a comprehensive overview. This study uses the FDA's Adverse Event Reporting System (FAERS) to explore the correlation between DM and medications.

Research design and methods

The study encompassed FAERS reports from January 2004 to June 2024. We coded and classified adverse events (AEs) using MedDRA and conducted multiple disproportionality analyses (ROR, PRR, BCPNN, MGPS) to examine drug-event associations and analyze the results.

Results

Using the "primary suspects" role code in FAERS, 1767 reports involving 353 drugs suspected of inducing DM were identified. Among 24 signal-positive drugs, cardiovascular

SUBMITTER: Bi J 

PROVIDER: S-EPMC12521234 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature