Remission trajectories and cognitive function in hospitalized youth with depressive episodes.

ABSTRACT:

Background

Depressive episodes in adolescents and young adults are a significant global health concern, marked by high prevalence, cognitive impairments, and elevated suicide risk. Despite their clinical importance, remission trajectories and cognitive function in hospitalized youth remain understudied, particularly in transdiagnostic contexts.

Methods

This retrospective cohort study analyzed electronic health records from 792 hospitalized patients (aged 13-22) with depressive episodes, using the Hamilton Depression Rating Scale (HDRS-17) and the Primary Cognitive Ability Test (PCAT III) to assess symptom trajectories and cognitive function. Gaussian Mixture Models identified distinct remission patterns, while linear mixed-effects models evaluated associations between depres

SUBMITTER: Yang J 

PROVIDER: S-EPMC12521248 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature