Impact of an aerosolized or intramuscular adenovirus type 5-vectored COVID-19 vaccine on Fc-mediated immune effector functions in a hybrid immunity population.

ABSTRACT:

Background

Beyond the role of neutralizing antibodies in protecting against SARS-CoV-2, Fc-mediated antibodies functions may offer additional immune defense. This study aimed to evaluate the Fc-mediated immune responses elicited by aerosolized and intramuscular Ad5-nCoV vaccines in a Chinese population with hybrid immunity.

Methods

Serum samples were collected from the immunogenicity sub-cohort within a multicenter, partially randomized platform trial comparing aerosolized and intramuscular adenovirus type 5-vectored COVID-19 vaccine (Ad5-nCoV) boosters in adults in China. Participants were enrolled approximately six months after an Omicron wave in late 2022, and randomized to receive a booster dose with aerosolized or intramuscular Ad5-nCoV. Fc-mediated immune responses to

SUBMITTER: Gan M 

PROVIDER: S-EPMC12521264 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature