Netrin-1 as a molecular mediator linking APOE ε4 to alzheimer's disease pathogenesis.

ABSTRACT: The ɛ4 allele of the apolipoprotein E (APOE) gene stands as the most significant genetic risk factor for Alzheimer's disease (AD), although the underlying mechanism linking APOE to the disease remains elusive. Netrin-1, has been found to inhibit Aβ production, reduce neuroinflammation, and regulate synaptic plasticity, thereby playing a role in AD. Recent reports suggest that Netrin-1 could be a key protein connecting APOE ɛ4 with Aβ and tau tangles. This study aims to investigate whether APOE regulates the expression or function of Netrin-1, thus influencing the risk of developing AD. The serum levels of Netrin-1 were notably reduced in patients with AD compared to healthy individuals, whereas interleukin-6 (IL-6) concentrations were higher in the AD group. patients harboring the APOE ε4

SUBMITTER: He B 

PROVIDER: S-EPMC12521370 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature