Pentanoate modulates B cells to suppress allergic contact hypersensitivity.

ABSTRACT: Allergic contact dermatitis (ACD) is a common T cell-mediated hypersensitivity reaction affecting the skin after exposure to an allergen. ACD is managed by antihistamines or steroids and avoiding exposure to allergens. Pentanoate is a short chain fatty acid with a therapeutic potential to modulate lymphocytes to secrete interlukin-10 (IL-10). Although IL-10 producing B cells are known to reduce inflammatory response, their role in ACD remains poorly understood. This study aims to investigate how B cells respond during ACD and how pentanoate influences them. Trinitrochlorobenzen (TNCB) was used to develop an in vivo model of contact hypersensitivity (CHS) in mice. Ear swelling and cellular analysis were used to examine allergic inflammatory reactions. Using flow cytometry, the B and T cell

SUBMITTER: Alhmoudi S 

PROVIDER: S-EPMC12521387 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature