Multi-omics tests identify novel shared genetic mechanisms of primary biliary cholestasis and sarcopenia.

ABSTRACT: Primary biliary cholangitis (PBC) may affect skeletal muscles through the muscle-liver axis, subsequently leading to sarcopenia. Our study aims to explore the unclear genetic relationships between PBC and sarcopenia. We investigated the shared genetic architecture of PBC and sarcopenia using advanced statistical genetics methods and genome-wide association summary data. We employed global and local genetic correlation to gain potential shared biological mechanisms. We identified risk single nucleotide polymorphisms (SNPs) and functionally annotated genomic multi-markers by conducting the unified test for molecular signatures. Finally, we prioritized fine-mapping analysis to emphasize the significant causal genes. Our study has identified significant genomic associations, suggesting the com

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12521401 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature