LAPTM5 exacerbates STING-mediated inflammation induced by LL-37 through stabilizing STING in rosacea.

ABSTRACT: Rosacea is a chronic inflammatory skin disorder linked to the antimicrobial peptide LL-37 and immune cells. STING, a key DNA-sensing adaptor, initiates innate immune responses, with excessive activation contributing to inflammation. This study investigates LAPTM5, a STING-interacting protein, and its role in rosacea. We observe elevated nuclear DNA fragmentation within the dermal lesions of rosacea patients and LL-37-induced rosacea-like mice. LAPTM5 and STING levels are upregulated in macrophages within rosacea lesions and LL-37-induced models, along with STING hyperactivation. LAPTM5 knockdown in macrophages reduces STING protein levels, signaling, and inflammatory responses under DMXAA and HT-DNA stimulation. LAPTM5 associates with STING and represses its K48- and K63-linked polyubiquit

SUBMITTER: Huang W 

PROVIDER: S-EPMC12521404 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature