Case Report: Clinical metastasis characteristics of lung adenosquamous carcinoma with <i>ROS1</i> rearrangement.

ABSTRACT: Adenosquamous carcinoma (ASC) of the lung is a rare and aggressive subtype of non-small-cell lung cancer, with a poor prognosis. Previous studies have revealed the existence of numerous oncogenic mutations shared between the adeno and squamous components, thereby implying a potential link between these two pathologies. Nevertheless, the genetic origin and underlying mechanisms of such a connection remain subjects of controversy. Here, we present a remarkable case of ASC where the primary tumor and mediastinal lymph node (LN) metastasis were adenosquamous, while the hilar LN metastasis was pure squamous cell carcinoma. Remarkably, a ROS1 rearrangement was identified in all lesions, strongly suggesting a common origin for the adeno-squamous components. In other words, ASC represents a

SUBMITTER: Chen X 

PROVIDER: S-EPMC12521446 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature