Single-cell transcriptome analysis reveals the potential heterogeneous mechanism of CD8⁺ T cell immune dysfunction in thyroid cancer.

ABSTRACT: Anaplastic thyroid cancer (ATC) and papillary thyroid carcinoma (PTC) exhibit significant differences in clinical behavior and immune microenvironments, particularly concerning the mechanisms underlying CD8⁺ T cell dysfunction. However, these specific mechanisms have yet to be thorThe original blots and abbreviations are presented in Supplemeoughly investigated. The present study utilized single-cell RNA sequencing (scRNA-seq) data to conduct a comprehensive analysis of CD8⁺ T cells in the thyroid tissues of patients diagnosed with ATC and PTC. The results of the study indicate that CD8⁺ T cells in ATC display disruptions in energy supply and marked signs of exhaustion. Conversely, CD8⁺ T cells in PTC are more prone to maintaining a stable expres

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12521488 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature