USP8 modulates primary ovarian insufficiency through regulation of Beclin1-dependent autophagy-induced ferroptosis.

ABSTRACT: The premature exhaustion of primordial follicles is a characteristic of primary ovarian insufficiency (POI), represents a profound disorder of ovarian function that leads to infertility, substantial impairments in daily activities, and enduring health risks. Despite its clinical significance, the underlying mechanisms of POI remain largely elusive. In this study, we investigated the potential role of ferroptosis, a form of programmed cell death associated with iron accumulation and lipid peroxidation, in the pathogenesis of POI.Our findings revealed a marked upregulation of USP8 expression in POI cases compared to controls. To further explore the functional significance of this observation, we manipulated USP8 expression in granulosa cells, a key cell type in ovarian function. Overexpressi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12521505 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature