Role of CaMKIIa reticular neurons of caudal medulla in control of posture.

ABSTRACT: Terrestrial quadrupeds stabilize dorsal-side-up body orientation (the vertical orientation of its dorso-ventral axis) through the postural control system, with supraspinal inputs, including those from the reticular formation, playing a central role. The contribution of specific molecularly identified reticular neuron populations to posture, however, has remained unclear. We investigated CaMKIIa-expressing reticular neurons (CaMKIIa-RNs) in the caudal medulla and their role in postural regulation. Using chemogenetic activation and inactivation in mice, we found that unilateral activation of CaMKIIa-RNs produced ipsilateral roll tilt of the head and trunk, driven by flexion/adduction of ipsilateral limbs and extension/abduction of contralateral limbs. This tilt was actively stabilized on a t

SUBMITTER: Zelenin PV 

PROVIDER: S-EPMC12521512 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature