Evaluating the association between TSH and FT4 levels and the incidence of metabolic syndrome: insights from the Tehran thyroid study using joint modeling.

ABSTRACT: This study aims to investigate the longitudinal association between thyroid-stimulating hormone (TSH), free thyroxine (FT4), and the incidence of metabolic syndrome (MetS) using joint modeling techniques over a ten-year follow-up in the Tehran Thyroid Study (TTS). Data from 1436 participants aged 20 years or older in the TTS cohort were analyzed. The study spanned four years, beginning in 1999 and concluding in 2012, with follow-up assessments conducted every three years. Longitudinal changes in logarithm-transformed TSH and FT4 levels were examined as time-varying exposures to evaluate their association with the incidence of metabolic syndrome (MetS). Over a median follow-up of 8.92 years, 574 new MetS cases were identified. Higher TSH levels were positively associated with MetS risk (HR:

SUBMITTER: Amirabadizadeh A 

PROVIDER: S-EPMC12521525 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature