Systems modeling and uncertainty quantification of AMP-activated protein kinase signaling.

ABSTRACT: AMP-activated protein kinase (AMPK) plays a key role in restoring cellular metabolic homeostasis after energy stress. Importantly, AMPK acts as a hub of metabolic signaling, integrating multiple inputs and acting on numerous downstream targets to activate catabolic processes and inhibit anabolic ones. Despite the importance of AMPK signaling, unlike other well-studied pathways, such as MAPK/ERK or NF-κB, only a handful of mechanistic models of AMPK signaling have been developed. Epistemic uncertainty in the biochemical mechanism of AMPK activation, combined with the complexity of the AMPK pathway, makes model development particularly challenging. Here, we leveraged uncertainty quantification (UQ) methods and recently developed AMPK biosensors to construct a new, data-informed model of AMPK

SUBMITTER: Linden-Santangeli N 

PROVIDER: S-EPMC12521545 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature