An integrated structural and immunoinformatic approach to design a multi-epitope based vaccine against the foot-and-mouth disease virus.

ABSTRACT: The Foot-and-mouth disease virus (FMDV) is highly contagious, affecting cloven-hoofed animals and causing significant economic losses to the livestock industry. Its high genetic variability complicates vaccine development, necessitating frequent updates to traditional inactivated vaccines. Multi-epitope-based vaccines (MEBVs) offer a promising alternative by incorporating immunogenic epitopes to elicit robust humoral and cell-mediated immune responses, thereby providing broader protection against diverse FMDV strains. Using in silico approaches, we designed a novel FMDV-targeting MBEV specifically tailored to the BoLA alleles to ensure optimal epitope selection for cattle. The MEBV included non-toxic, antigenic, and non-allergenic epitopes combined with β-defensin 3 adjuvants, PADRE sequen

SUBMITTER: Sahoo S 

PROVIDER: S-EPMC12521559 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature