Multi-omic network inference from time-series data.

ABSTRACT: Biological phenotypes emerge from complex interactions across molecular layers. Yet, data-driven approaches to infer these regulatory networks have primarily focused on single-omic studies, overlooking inter-layer regulatory relationships. To address these limitations, we developed MINIE, a computational method that integrates multi-omic data from bulk metabolomics and single-cell transcriptomics through a Bayesian regression approach that explicitly models the timescale separation between molecular layers. We validate the method on both simulated datasets and experimental Parkinson's disease data. MINIE exhibits accurate and robust predictive performance across and within omic layers, including curated multi-omic networks and the lac operon. Benchmarking demonstrated significant improveme

SUBMITTER: Moscardo Garcia M 

PROVIDER: S-EPMC12521560 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature