Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons.

ABSTRACT: Melanocortin-4 receptor-expressing neurons in the paraventricular nucleus of the hypothalamus (PVH^MC4R) integrate hunger-promoting and hunger-suppressing signals to regulate satiety. Food consumption-evoked responses in PVH^MC4R neurons increase gradually during meal consumption to promote satiety, and disrupting this process drives massive obesity. These critical satiety neurons are strongly affected by a high-fat diet, yet the impact on their functional properties remains unknown. We used fiber photometry to track PVH^MC4R neurons' responses to the consumption of drops of milkshake in animals fed a chow diet or a high-fat diet (HFD), both after obesity was established and after its reversal. PVH^MC4R neurons in HFD-fed animals showed greater consu

SUBMITTER: Porniece M 

PROVIDER: S-EPMC12521569 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature