Correlation between C-peptide and diabetic retinopathy in patients with type 2 diabetes mellitus: a cross-sectional study.

ABSTRACT: This study aimed to investigate the relationship between C-peptide levels, specifically 180-min postprandial C-peptide levels, and diabetic retinopathy (DR) in individuals with type 2 diabetes. This cross-sectional study involved 1545 participants divided into two groups: one with diabetic retinopathy (742 individuals) and one without (803 individuals). To assess the connection between C-peptide levels and DR, multivariate logistic regression and Spearman correlation analysis were performed, including subgroup analyses to ensure robustness of the results. Compared with individuals without DR, individuals with DR had significantly lower postprandial C-peptide levels. Additionally, these postprandial C-peptide levels were inversely correlated with Haemoglobin A1c (HbA1c), fasting blood gluco

SUBMITTER: Li Y 

PROVIDER: S-EPMC12521573 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature