Bioinformatics identification of key genes correlating NOD1 and Endoplasmic Reticulum stress in Hepatitis B virus-induced acute liver failure.

ABSTRACT: Endoplasmic reticulum stress (ERS) has been implicated in a range of biological processes, yet its specific involvement in Hepatitis B virus-associated acute liver failure (HBV-ALF) remains poorly understood. This study aimed to identify key ERS-related genes (ERGs) and elucidate their underlying mechanisms in HBV-ALF. Publicly available HBV-ALF-related datasets (GSE38941, GSE62029) and ERGs were analyzed. Intersection genes were determined by overlapping differentially expressed genes from both datasets with ERGs, and genes showing strong correlation with NOD1 were selected as candidates. The BottleNeck algorithm in the Cytohubba plugin and machine learning-based screening were subsequently applied to refine key gene selection. Diagnostic performance was assessed using ROC curves, while a

SUBMITTER: Deng F 

PROVIDER: S-EPMC12521598 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature