Edge participation coefficient unveiling the developmental dynamics of neonatal functional connectome.

ABSTRACT: Understanding how the brain's functional connections develop during infancy is crucial for uncovering the complexities of early neural maturation. Traditional node-based analyses have advanced our knowledge, but may overlook the transient dynamics of interregional connectivity. Leveraging the large neonatal functional MRI dataset from the Developing Human Connectome Project (n = 781, including 494 full-term and 287 preterm infants), we introduce an edge-centric metric to quantify cross-module functional integration. Here we show that preterm infants exhibit higher edge participation coefficients than full-term peers, suggesting delayed network specialization. We mapped developmental changes in edge participation coefficients and found that between-network connections-particularly those inv

SUBMITTER: Fang T 

PROVIDER: S-EPMC12521645 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature