Endoscopic therapy versus surgical resection for rectal gastrointestinal stromal tumors: a population-based comparative analysis of long-term survival outcomes.

ABSTRACT:

Background

Rectal gastrointestinal stromal tumors (GISTs) are relatively rare, and the long-term survival outcomes of endoscopic therapy (ET) versus surgical resection (SR) remain uncertain. This study aims to assess the long-term survival in patients with rectal GISTs treated with either ET or SR.

Methods

Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was implemented to reduce selection bias in the comparative analyses. The impact of demographic and clinical features on overall survival (OS) and cancer-specific survival (CSS) was evaluated through Kaplan-Meier analyses and the use of multivariate Cox proportional hazards models.

Results

A total of 239 patients were included, with 146 underg

SUBMITTER: Ding J 

PROVIDER: S-EPMC12521689 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature