Depletion, metabolism, and risk assessment of clopidol in broilers.

ABSTRACT: The anticoccidial agents clopidol is widely used in livestock production to prevent coccidiosis; however, the residues that remain in edible tissues pose a risk to human consumers. This study investigated the residue depletion and metabolism of orally administered radiolabeled [³H]-clopidol (25 mg/kg body weight) in the liver, muscle, kidney, and fat. The analytical methods employed for all tissues were subjected to rigorous validation to ensure their selectivity, linearity (r² ≥ 0.999), system suitability (0.4%), accuracy (89.5-102.5%), and precision (> 5.2%). The validated method using radio-HPLC and liquid scintillation counting indicated that the highest concentrations of clopidol residues were observed 6 h post-administration in the liver (28.81 ± 2.41 mg/kg), muscle (14.31

SUBMITTER: Jeong SH 

PROVIDER: S-EPMC12521738 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature