Biomimetic KcsA channels enabled by 1D MOF-in-2D COF.

ABSTRACT: Highly permeable and selective biomimetic membranes that can feel and recognize valuable ion species have attracted enthusiastic interest due to their analogous behavior with biological ion channels and potential applications in rigorous ion sieving. However, designing and developing single-species selective membranes that can isolate monovalent cations such as K⁺/Na⁺ remains a tremendous challenge due to the sub-nanometer ion size, as well as the angstrom-sized difference. Considering the non-homogeneous heterostructure of KcsA channels and -COOH groups generally showing lower K⁺ affinity, we propose the 1D MOF (rich in -COOH groups)-in-2D COF concept, aiming to enhance K⁺/Na⁺ separation through strategic construction of heterogeneous

SUBMITTER: Sun Q 

PROVIDER: S-EPMC12521740 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature