Mitochondrial dysfunction alters early endosome trafficking via microtubule reorganization.

ABSTRACT: Mitochondria are essential for bioenergetics and cellular processes including cell differentiation and immunity; alterations in these processes cause a wide range of muscular and neurological pathologies. Although these pathologies have traditionally been associated with ATP deficits, mitochondrial dysfunction also leads to reactive oxygen species (ROS) generation, inflammation, and alterations in the function of other organelles. Although the negative impact of mitochondrial dysfunction on lysosomal activity is established, the relationship between mitochondria and the rest of the endocytic compartment remains poorly understood. Here, we show that inhibiting mitochondrial activity through genetic and chemical approaches causes early endosome (EE) perinuclear aggregation and impairs cargo

SUBMITTER: Vishwakarma A 

PROVIDER: S-EPMC12521748 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature