Cost-effectiveness of population-wide screening for intracranial aneurysms revisited in light of potential diagnostic developments.

ABSTRACT:

Background

Preventive treatment of unruptured intracranial aneurysms (UIAs) has the potential to reduce aneurysmal subarachnoid hemorrhage (SAH) incidence. Population-wide screening (PWS) for UIAs has been disregarded, as it remains unclear how to manage low-risk UIAs. Higher cost for SAH treatment, along with improvements in UIA treatment decision-making, might improve the risk-benefit and cost-benefit ratios for PWS. Currently, blood-based screening tests for UIAs are under development and might be suitable for use in PWS.

Aims

This study sets out to identify what health economic criteria should be met by a hypothetical UIA screening test to justify PWS.

Methods

A Markov model was built to compare PWS versus standard of care. Model parameterization was done using re

SUBMITTER: Veldeman M 

PROVIDER: S-EPMC12521774 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature