The dosimetric and radiobiological effects of rotational errors in breast cancer radiotherapy.

ABSTRACT:

Purpose

This study aimed to assess the dosimetric and radiobiological consequences of rotational errors in breast cancer radiotherapy.

Methods

A retrospective analysis involving 80 breast cancer patients was performed. We simulated 124 rotational scenarios across three axes (yaw, pitch, and roll) to generate rotated dose distributions, then evaluated their dosimetric effects alongside tumor control probability (TCP) and normal tissue complication probability (NTCP) for the target and organs at risk (OARs).

Results

Rotational errors caused significant dose deviations. The D95 for PTV, heart, ipsilateral lung, contralateral breast, and left anterior descending artery (LAD_V40) in rotated dose distributions showed statistical significance compared to the origin

SUBMITTER: Liu D 

PROVIDER: S-EPMC12521787 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature