Serum Levels of 54 Cytokines and Chemokines Reveal Distinct Inflammatory Signatures in Ankylosing Spondylitis.

ABSTRACT:

Background

Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disorder predominantly involving the axial skeleton. Understanding the cytokine and chemokine signatures in AS is crucial for elucidating disease mechanisms and identifying potential diagnostic biomarkers.

Methods

Serum samples from 31 AS patients and 20 age-matched healthy controls (HCs) were analyzed. The concentrations of 54 cytokines, chemokines, and angiogenesis-related factors were measured using a Meso Scale Discovery (MSD) electrochemiluminescence immunoassay. Data analysis included statistical comparison of serum cytokine levels, heatmap clustering, principal component analysis (PCA), and receiver operating characteristic (ROC) curve analysis. Validation was performed using peripheral blood

SUBMITTER: Li H 

PROVIDER: S-EPMC12521873 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature