Mapping Use of High Dose or Long-Term Oral Glucocorticoids and Steroid-Sparing Strategies in Adults With Chronic Conditions: A Rapid Scoping Review of Reviews.

ABSTRACT:

Purpose

Oral glucocorticoids (OGCs) have a broad range of uses and are effective in treating numerous conditions. However, it is commonly acknowledged that OGCs at high doses or over long periods have a burden of toxicity. Despite the use of steroid-sparing therapies, OGCs continue to be prescribed to treat a wide range of immune and inflammatory conditions. We aimed to address the following research questions: (1) what are the contemporary indications for high dose and/or long-term OGCs? (2) what patterns of use are described in the literature for high dose and/or long-term OGCs? (3) which evidence do we have for chronic conditions related to well-established steroid-sparing strategies and tapering regimes for OGCs? (4) what adverse effects have been reported with high dose and/or

SUBMITTER: Moore E 

PROVIDER: S-EPMC12521885 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature