Transrectal Ultrasound-Guided Prostate Biopsy with and without PSMA-PET-Targeted Prostate Biopsy for Prostate Cancer Diagnosis.

ABSTRACT:

Purpose

Transrectal ultrasound-guided prostate biopsy (TRUS-GB) is associated with the underdiagnosis of prostate cancer, and prostate-specific membrane antigen (PSMA)-PET-targeted prostate biopsy (PSMA-TB) may reduce the misclassification of prostate cancer. The primary outcome of the study was the accuracy of the two methods in identifying clinically significant prostate cancer (csPCa). The secondary outcomes included accuracy in identifying clinically insignificant prostate cancer (GG1) and GG3 or greater tumors, cancer detection stratified by the previous biopsy status, and the detection rate of csPCa using the combination of PSMA-TB and TRUS-GB.

Patients and methods

In this multicenter, two-arm, randomized study, biopsy-naïve patients suspected of having prostate cancer

SUBMITTER: Jiao J 

PROVIDER: S-EPMC12521911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature