Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs.

ABSTRACT:

Purpose

Laser interstitial thermal therapy (LITT) is a minimally invasive surgical intervention permitting thermal ablation of intracranial targets such as tumors, radiation necrosis, or epileptogenic brain, including lesions that are deep, difficult to access, or recurrent that would otherwise have few viable surgical options. Despite its advantages, LITT has several limitations, including a restricted effective treatment zone (approximately 3 cm) and a limited ability to distinguish tumor margins from healthy brain tissue. Few viable animal models of appropriate size exist for studying LITT's impact on these disorders or for optimizing the technology and obviating its current limitations. Pet dogs develop these same disorders at similar rates to humans. We hypothesized that LITT

SUBMITTER: Mariani CL 

PROVIDER: S-EPMC12521916 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature