Tyro3 deletion is protective in experimental autoimmune encephalomyelitis.

ABSTRACT: Multiple sclerosis is a complex neurological disorder, involving both the adaptive and innate immune systems as well as the CNS. The interaction between these systems is complex, and as such, there is the potential for MS therapies to have conflicting effects in different tissues. It is therefore critical that in addition to tissue-specific studies, system-wide effects of potential therapeutic pathways are explored. The circulating protein Gas6 is a promising therapy to promote remyelination in people with multiple sclerosis. Gas6 is a ligand for the TAM family of receptor protein tyrosine kinases that are widely expressed in the immune system and in the CNS, highlighting the potential for multi-system effects as a result of Gas6 treatment. In this study, we demonstrate that global genetic

SUBMITTER: Binder MD 

PROVIDER: S-EPMC12521954 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature