The Effects of <i>Chlorella vulgaris</i> on Polycystic Ovary Syndrome in Mice.

ABSTRACT: This study aimed to investigate the therapeutic effects of Chlorella on ovarian hormone levels, steroidogenic enzymes, ovarian dysfunction, oxidative stress, and gut microbiota composition in a mouse model of polycystic ovary syndrome (PCOS). A PCOS mouse model was established using dehydroepiandrosterone (DHEA) induction. The effects of Chlorella supplementation were evaluated in vivo to determine its potential for alleviating PCOS-related symptoms. Chlorella treatment effectively reduced testosterone (T) and luteinizing hormone (LH) levels in mice with PCOS. Additionally, Chlorella modulated the expression of oxidative stress-related genes and improved ovarian morphology and function. Notably, Chlorella also restored the gut microbiota from PCOS-associa

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12522022 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature