Asthma Phenotype Progression in Children and Adolescents: A Single Center Experience.

ABSTRACT:

Background

Asthma phenotype has implications for presentation and treatment selection.

Methods

This was a retrospective study of patients attending a pediatric pulmonary clinic (2009-2015) with EHR data available for phenotyping (allergic, eosinophilic/non-allergic or non-allergic/non-eosinophilic). Patients were classified by age. A multinomial regression model examined factors associated with phenotype. A logistic regression model examined factors associated with a change in phenotype (present/absent).

Results

There were 2042 patients included. Approximately 44% of participants were allergic, 17% eosinophilic/non-allergic and 39% non-allergic/non-eosinophilic. Among children 0-4 years, age of asthma onset (aOR 1.42, 95% CI 1.21, 1.65) and mean exacerbations (aOR 1.2

SUBMITTER: Schuler CL 

PROVIDER: S-EPMC12522030 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature