Classification of prostatic adenocarcinoma as favourable/unfavourable histology has high interobserver agreement in prostate needle core biopsies.

ABSTRACT:

Aims

A dichotomous classifier for prostatic adenocarcinoma, favourable and unfavourable histology, was recently proposed to optimize metastasis prediction. We evaluate interobserver agreement for its classification.

Methods and results

Fifty biopsies with prostatic adenocarcinoma were selected. One slide per biopsy was scanned using the Aperio AT2 scanner (20x) and viewed in Leica Web Viewer. Ten pathologists reviewed each slide after completing a training module. Biopsies were scored for Grade Group (1-5) and presence of unfavourable histology. Forty-one of 50 biopsies (82%) had unanimous consensus [13 (32%) unfavourable and 28 (68%) favourable], 47 (94%) for at least 9 of 10 reviewers, and 48 (96%) for at least 8 of 10 reviewers. Percent agreement for favourable/unfavourab

SUBMITTER: Ding CC 

PROVIDER: S-EPMC12522031 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature