Determinants of oncologic outcomes in high-grade organ-confined prostate cancer after prostatectomy.

ABSTRACT:

Aims

In radical prostatectomy (RP), Grade Group (GG) 4/5 prostate cancer [high-grade prostate cancer (HGPC) hereafter] is often associated with extension beyond the prostate and positive surgical margins. Hence, there is limited information on post-RP outcomes of patients with completely resected HGPC confined to the prostate (pT2).

Materials and methods

Clinical outcomes were assessed in a cohort of patients with pT2 HGPC and negative surgical margins using Kaplan-Meier statistics and Cox regression analysis.

Results and conclusion

Four hundred and seven RPs were initially assessed: 236 (58%) with GG 4 and 171 (42%) with GG 5 prostate cancer (PCa). Survival analysis was performed on subsets of patients with available follow-up (BCR: n = 343, metastases: n = 347) to i

SUBMITTER: Youssef R 

PROVIDER: S-EPMC12522032 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature