Violacein-Loaded Outer Membrane Vesicles from <i>Salmonella enterica</i> Exhibit Potent Anti-Melanoma Activity <i>in Vitro</i> and <i>in Vivo</i>.

ABSTRACT: Violacein exhibits antitumor activity, indicating potential for future clinical application. However, an efficient delivery system is required for the clinical use of this hydrophobic compound. Effective delivery systems can enhance the solubility and bioavailability of hydrophobic compounds like violacein, facilitating its clinical application for antitumor therapy. Recent studies have demonstrated that outer membrane vesicles (OMVs) can serve as nanocarriers. This article constitutes the first report to present both in vivo and in vitro investigations of OMVs derived from a hypervesiculating mutant of Salmonella enterica Typhimurium as a delivery vehicle for violacein. In this study, S. enterica Typhimurium ΔtolRA (with a hypervesiculated phenotype) was

SUBMITTER: Jorge GP 

PROVIDER: S-EPMC12522090 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature